- ALOE VERA
- ANGELICA SPECIES
- BETA SITOSTEROL
- BLACK COHOSH
- CERNITIN POLLEN EXTRACT
- CHASTE TREE
- CHINESE SKULL CAP
- COLEUS FORSKOHLII
- DEVIL'S CLAW
- FLAXSEED AND FLAXSEED POWDER
- GINKGO BILOBA
- GOTU KOLA
- HORSECHESTNUT SEED
- HUPERZINE A
- KAVA (PIPER METHYSTICUM)
- MILK THISTLE
- MUIRA PUAMA
- RED CLOVER
- REISHI MUSHROOM
- SAW PALMETTO
- SHIITAKE MUSHROOM
- ST. JOHN'S WORT
- STINGING NETTLE
- UVA URSI
- WHITE WILLOW BARK
- WILD YAM
Comprehensive Guide to Angelica Species
(Angelica sinesis, e.g. Dong Quai)
The primary active constituents for menopausal and menstrual symptoms are coumarin and phytoestrogens. Angelica phytoestrogens exhibit 1:400 the biological activity of animal-based estrogens (i.e., Premarin).
As a general statement, phytoestrogens (plant-based estrogens) compete with the body’s own estrogens for binding sites on estrogen receptors on reproductive and other tissues, helping to guard against estrogen over-stimulation, which can exacerbate or cause PMS and related symptoms. During menopause, when the body’s estrogen secretion drops off, phytoestrogens can provide estrogenic support to help reduce hot flashes and other menopausal symptoms.1,2,4,5 (see Black Cohosh, Soy Isoflavones and Red Clover in this document for a more detailed explanation of phytoestrogens).
Angelica may reduce smooth muscle spasm, easing cramping and related menstrual symptoms.
Management of PMS and Menopausal Symptoms:
Powdered root or as a tea: 1-2 gms, 3 times per day
Tincture (1:5): 4 ml (1 teaspoon), 3 times per day
Fluid extract: 1 ml (1/4 teaspoon), 3 times per day
Solid Extract (capsule) – 200 mg, two times daily, standardized to 0.8-1.1% ligustilide content.
Anticoagulants (warfarin, coumadin, aspirin etc) – animal studies demonstrate that Angelica Species potentiates the anti-clotting effects of warfarin and thereby, may increase the chance of a serious bleeding disorder. Several reports of this consequence in humans have been reported, even in women not taking concurrent anticoagulant therapy. Therefore, women should not take Dong Quai concurrently with any anticoagulant drug.6,7,8,9 (note that Black Cohosh, Soy Isoflavones, Gamma Oryzanol and Chasteberry are not associated with this risk).
Pregnant women - increased risk of birth defects has occurred with maternal intakes as low as 25,000 IU/day.
2. Murray MT, The Healing Power of Herbs (2nd edition), Prima Publishing, 1995.
3. Natural Health Products Encyclopedia. www.consumerlab.com: Dong Quai
4. Hikino H: Recent research on Oriental medicinal plants. Econ Med Plant Res. 1985; 1: 53-85
5. Zhu DPQ: Dong Quai. Am J Chin Med. 1985;15: 117-125.
6. Heck A, et al. Potential interactions between alternative therapies and warfarin. Am J Health-Syst Pharm.2000;57 (13): 1221-1227
7. Lo AC, et al. Danggui (Angelica sinensis). Affects the Pharmacodynamics But Not the Pharmacokinetics of Warfarin in Rabbits. Eur J Drug Metab and Pharmacokinet. 1995;20(1): 55-60
8. Ellis GR, Stephens MR. Untitled (brief case report). BMJ 1999;319:650
9. Page RL II, Lawrence JD. Potentiation of Warfarin by Dong Quai.Pharmacotherapy 1999;19(7):870-76