CoQ10 Supplementation Reduces Risk Parameters in Heart Disease Patients 04/09/12
It is well established that inflammation in the blood vessel wall increases risk for heart attack and other cardiovascular events. Inflammation in the blood vessel wall manifests as high blood levels of interleukin-6 (IL-6) and other inflammatory markers, such as C-Reactive Protein (CRP). In a study published in 2012, involving 40 subjects with coronary artery disease (CAD), supplementation with coenzyme Q10 (150 mg/d) was found to decrease key markers of inflammation in these patients.
Subjects were randomly assigned to one of 3 groups: 1) placebo; 2) 60 mg coQ10 per day or 3) 150 mg coQ10 per day, for a period of 12 weeks. The results showed that blood levels of CoQ10 increased significantly in both CoQ10-supplemented groups, and after 12 weeks, levels of the inflammatory marker IL-6 were significantly lower in the 150 mg/d CoQ10 group. The results also showed lower free radical damage end-products (malondialdehyde) in the blood of patients supplemented with 150 mg of CoQ10 per day. These are important factors in the global managment of cardiovascular disease.
This study suggests that patients with known heart disease, or high risk cardiovascular patients, require a daily dosage of 15o mg of CoQ10 per day to significantly reduce blood vessel wall inflammation and free radical damage, both of which are associated with increased risk of heart attack and/or serious vascular events. In my view, I like patients to take a supplement that contains CoQ10 (30 mg), Hawthorn (37.5 mg), and Quercetin (50 mg). Hawthorn works with CoQ10 to increase energy in the heart muscle, improves circulation in the coronary arteries and helps to regulate blood pressure. Quercetin helps to lower CRP and quenches free radicals, as a water-soluble antioxidant. CoQ10 is a fat-soluble antioxidant. The combination of these three nutrients in one capsule is an essential aspect of heart health for everyone by age 45.
The prevention dosage is one capsule per day by age 45, two capsules per day by age 55, and three capsules per day after age 60. Heart patients should consider 5 capsules per day. One precautionary note, patients taking digitalis or digoxin should not take supplements containing hawthorn.
Lee BJ, Huang YC. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease., et al. Nutrition, 2012 Feb 16.
Furthermore, levels of malondialdehyde were significantly lower in the 150 mg/d CoQ10 group as well, and greater levels of superoxide dismutase activities were found in both the 60 mg/d and 150 mg/d CoQ10 groups.
Also remember that if your cholesterol or triglcyerides are high, you should download a free copy of my ebook, which explains how to lower cholesterol and triglycerides naturally. These are important risk factors for heart disease as you know. Here is the link to my free ebook on this subject: http://www.meschinohealth.com/LP/Lower_Your_Cholesterol/
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