Getting The Right Dosage of Green Tea Catechins 06/09/14

Sometimes in life good things happen by accident. Such is the case with the therapeutic dosage of catechins from decaffeinated green tea. Let me quickly explain. When I first formulated Adeeva Body Burn, which helps burn fat, improves glucose regulation and supports lean mass gains, I combined chromium with hydroxycitric acid (HCA) and an herb called Coleus forskolin.

However, a few years ago it was shown that Coleus forskolin may pose a risk in patients taking certain cardiovascular medications. At about the same time clinical studies had emerged showing that catechins, from decaffeinated green tea, could help over weight patients lose body fat in absence of making any changes to their diet or physical activity program. Experimental studies showed that one of the ways that catechins reduced body fat was by turning on the body’s brown fat activity. Brown fat essentially burns excess calories and gives them off to the environment as heat, thus increasing thermogenesis or what’s known as the specific dynamic action of food (SDA). The net result in clinical studies showed a significant decrease in body weight and body fat, compared to  the control group. (1,2,3,4) So, I removed the Coleus forskolin and replaced it with the dosage of catechins proven to reduce body fat in overweight subjects.

Weight Loss, Blood Pressure, Glucose Control, Decreased Lipids and Inflammation

More good news about green tea catechins was published in June 2012 in Nutrition Research. Researchers showed that overweight patients with high blood pressure experienced significant improvement in blood pressure, insulin resistance, blood sugar levels, LDL-cholesterol, HDL-cholesterol and CRP levels (a marker for inflammation in blood vessels linked to increased risk for heart attacks, and joint inflammation) when supplemented with catechins. In this study, researchers followed 56 obese, hypertensive (high blood pressure) men and women for three months. The group supplementing green tea catechins showed impressive improvement in each of these parameters compared to the placebo group. The study authors concluded that: “daily supplementation [of green tea extract] favorably influences blood pressure, insulin resistance, inflammation and oxidative stress, and lipid profile in patients with obesity-related hypertension.” (5)

Prostate and Breast Cancer

Experimental studies also showed that catechins may have important anti-cancer effects, especially in regard to breast and prostate cancer. Since the year 2006 several human studies have shown that patients with breast cancer, localized prostate cancer and precancerous changes within the prostate gland, have benefited from catechin supplementation. In breast cancer patients awaiting surgery, catechin supplementation induced cell suicide (apoptosis) of some of the tumor cells, reduced their ability to form new blood vessels, and helped to improve other biomarkers linked to risk of metastatis and disease progression.  In men with precancerous changes within the prostate gland, a high-percentage (93%) of men given catechin supplementation experienced no further progression of their condition to overt prostate cancer, whereas 30% of the control developed prostate cancer within one year. And in men with localized prostate cancer, catechin supplementation lowered the PSA and other biomarkers linked to prostate cancer progression (VEGF, HGF, IGF-1).  As such, many experts believe that green tea catechins may help to prevent breast and prostate cancer, as well as providing an important part of the adjunctive nutritional management of these diseases. (5,7,8)

So, What Dosage Works?

As good fortune would have it the catechin supplement dosage shown to help patients lose weight, decrease body fat, improve glucose, lipid, and blood pressure regulation, reduce inflammatory markers, and exert important anti-cancer effects on prostate and breast tissue, has been already been formulated into the Adeeva Body Burn supplement.  The recommended dosage of Body Burn is three capsule per day (but you take up to 6 capsules), which provides 600 – 1200 mg of decaffeinated green tea extract, of which 80% is comprised of catechins.  This is the dosage (3 capsules per day) that showed good results with weight loss patients, but the same dosage range has been shown to favourably affect outcomes for high blood sugar, high blood pressure, high cholesterol and triglycerides as well as to improve biomarkers of inflammation (2-3 capsule per day) and to improve outcomes and biomarkers in cases of breast and prostate cancer (3-6 capsules per day).

So, I personally take 3 capsules of Body Burn per day, as part of my supplement regiment. I would recommend the same to overweight patients, individuals using supplements as a means to help prevent cancer, and to improve glucose, lipid and blood pressure regulation in select patients with these needs.

References:

  1. Nagao T, Komine Y, Soga S, Meguro S, Hase T, Tanaka Y, Tokimitsu I. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr 2005-81; 1:122-129. 2005
  2. Maki KC,  Reeves MS,  Farmer M, et al. Tea catechins and exercise-induced weight loss. The Journal of Nutritiondoi: 10.3945/jn. 108098293
  3. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord 2000;24:252–8.
  4. Dulloo AG, Duret C, Rohrer D, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999;70:1040–5.
  5. 5.      Pawel Bogdanski, Joanna Suliburska, Monika Szulinska, Marta Stepien, Danuta Pupek-Musialik, Anna Jablecka.  “Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.” Nutrition Research, 20 June 2012.
  6. Bettuzzi S, Brausi M, Rizzi F et al. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study. Cancer Res January 15, 2006 66; 1234
  7. McLarty J, Bigelow R, Smith M et al. Tea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro. Cancer Prev Res July 2009 2; 673
  8. http://www.eurekalert.org/pub_releases/2012-10/aafc-moa101112.php

 

 

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