Interactions Between Herbal Medicines And Prescription Drugs

In recent years, the general public has embraced the practice of taking dietary supplements as a means to help optimize their health, slow the aging process or address specific health concerns. In addition to the use of vitamin and mineral supplements, the population has also acknowledged the potential health-promoting benefits of various herbal remedies.

Quoting from U.S. statistics, the percentage of the population using herbal products grew from 2.5% in 1990 to 12.5% in 1997. (1) This made herbal product use second only to relaxation techniques, among various complementary therapies. In 1997, annual out-of-pocket expenditures for herbal medicinal products in the United States were estimated at $5.1 billion. (1)

Many patients are reluctant to disclose their use of alternative therapies to their physician. In fact, 60% of patients fall into this category. (1)

In the case of drug-nutrient interactions, this may raise some concern as certain natural agents can potentiate or modify the action of certain prescription medications. More specifically, drug-herb interactions may be at either the pharmacokinetic or pharmacodynamic level. Pharmokinetics is the study of what our bodies do to medicine. This includes the study of the absorption of medicine, its distribution throughout the tissues of the body, and its elimination from the body through metabolism and excretion.

Pharmacodynamics is the study of what medicines do to the body.

Drug-herbal interactions are of greatest concern when patients are taking drugs with a narrow therapeutic window. The therapeutic window is the relationship between plasma concentrations that achieve therapeutic effects and those that result in toxic effects. Drugs with particularly narrow therapeutic windows are prone to adverse interactions with other drugs, and with herbal products. Drugs with narrow therapeutic windows include warfarin, digoxin, theophylline, phenytoin, and Phenobarbital.

Generally speaking, the most important drug-nutrient interactions to guard against include bleeding disorders (including bleeding into the brain), upsetting brain chemistry (serotonin syndrome, cholinergic syndrome, triggering bipolar disease etc.), cardiac glycoside toxicity, and toxicity to internal organs (liver disease) (2).

Bleeding Disorders – Bleeding disorders can be caused by any herb that contains a significant concentration of anti-coagulant active ingredients, when taken concurrently with anti-coagulant medications, such as aspirin, warfarin, coumadin Plavix etc. Herbs such as red clover and dong quai (Angelica species) contain coumarins, which can potentiate the effects of anti-coagulant drugs. Ginkgo biloba and devil’s claw have also been shown to cause bleeding disorders in humans, sometimes in the absence of concurrent anti-coagulant medications use. Their active ingredients are known to significantly interfere with normal platelet function. Feverfew (a herb used to treat migraine headaches), ginger, turmeric and white willow extract may also induce a mild anti-coagulant effect, but to date, this has not been shown to occur to an appreciable degree in humans. Nor have any bleeding disorders been reported with use of these herbal agents (2,3,4,5).

Brain Chemistry Disturbances – as a rule, it is imperative not to recommend any natural health product that directly affects brain neurotransmitter concentrations if the patient is currently taking any medication that is aimed at altering mood (e.g. Prozac, tricyclic antidepressants, Alzheimer’s medications, L-Dopa etc.). The use of any herbal of accessory nutrient, such as St. John’s Wort or 5- hydroxytryptophan, (5-HTP) that elevate serotonin concentrations, in conjunction with an antidepressant medication, can result in serotonin syndrome – a life threatening condition characterized by excess serotonin concentrations. Signs and symptoms of serotonin syndrome include confusion, agitation, rapid heart rate, high blood pressure, muscle jerks, loss of coordination, sweating, shivering, fever as well as rapid breathing, coma and death.

Herbal supplements that elevate acetylcholine concentrations in the brain (huperzine A, bacopa monniera, phosphatidylserine, acetyl-L carnitine, DMAE-dimethylamino ethanol) have the potential to cause cholinergic syndrome, if taken concurrently with drugs used to treat Alzheimer’s disease and dementia, which slow the break down of acetylcholine (acetylcholinesterase inhibitors – donepezil, tacrine). The signs and symptoms of cholinergic syndrome include vomiting, excess saliva and tear production, increased sweating and bradycardia (6,7,8,9,10,18)

Cardiac Glycoside Toxicity – the herbal agent known as hawthorn works in the body in a similar fashion as other cardiac glycoside drugs, such as digoxin and digitalis.  Cardiac glycosides increase the intra-muscular concentrations of cyclic AMP (cAMP), from which cardiac muscle synthesizes ADP and ATP. ATP is then used as the energy source to power the muscular contraction of the heart with each heart beat. Drugs such as digoxin and digitalis have a very narrow margin of safety, and thus the concurrent use of hawthorn may easily produce toxicity, with potentially life threatening consequences (11,12,18)

The following represents the most significant possible drug-herb interactions and the potential adverse effects:

References

1. Eisenberg DM, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 1998; 280:1569-75
2. McNeill J. Interactions between herbal and conventional medicines. Can J Cont Med Edu. 1999. vol. No 12: 97-113
3. Matthews MKJ. Association of ginkgo biloba with intracerebral hemorrhage. Neurology 1998; 50:1933-4
4. Rosenblatt M, Mindel J. spontaneous hyphema associated with ingestion of ginkgo biloba. N Engl J Med 1997; 336: 1108
5. Janetzky K, Morreale AP. Probable interactions between warfarin and ginseng. Am J Health Syst Pharm 1997; 336:1108
6. Dandekar UP, Chandra RS, Dalvi S S, et al. Analysis of a clinically important interaction between phenytoin and Shankhapushpi, an Ayurvedic preparation. J Ethnopharmacol 1992; 35:285-8
7. Bladt S, Wagner H. Inhibition of MAO by fractions and constituents of Hypericum extract. J Geriatric Psychiatric Neurology 1994; 7:557-9
8. Jones BD, Runikis AM. Interaction of with phenelzinc. J Clin Psychopharmacol 1987; 7:201-2
9. Shader RI, Greenblatt DJ. Bees, ginseng and MAOIs revisited. J Clin Psychopharmacol 1988; 8:235
10. D’Arcy PF. Adverse reactions and interactions with herbal medicines. Part 2-Drug interactions. Adverse Drug React Toxicol Rev 1993; 12:147-62
11. Fushimi R, Tachi J, Amino N, et al. Chinese medicine interfering with digoxin immunoassays. Lancet 1989; 1:339
12. Fushimi R, Yamanishi H, Inoue M, et al. Digoxin immunoassay that avoids cross-reactivity from Chinese medicines. Clin Chem 1995; 41:621
13. Rowin J, Lewis SL. spontaneous bilateral subdural hematomas associated with chronic ginkgo biloba ingestion. Neurology 1996; 46: 1775-6
14. McRae, S. Elevated serum digoxin in a patient taking digoxin and Siberian ginseng. Can med Assoc J 1996; 155:293-5
15. Almeida JC, Grimsley EW. coma from the health food store; interaction between kava and alprazolam. Ann Intern Med 1996; 125:940-1
16. Santos MS, Ferreira F, Faro C, et al. The amount of GABA present in aqueous extracts of valerian is sufficient to account for [3H]GABA release in synaptosomes. Planta Med 1994: 60:476-6
17. Leuschner J, Muller J, Rudmann, M. Characterization of the central nervous depressant activity of a commercially available valerian root extract. Arzneimiteelforschung 1993; 43:638-41
18. Consumerslab.com: www.consumerslab.com